Session Index

Biophotonics and Biomedical Imaging

Poster Session I
Thursday, Dec. 7, 2017  12:30-14:00
Presider: -
Room: International Research Building 5F
Paper No.  2017-THU-P0601-P001
Yao-Chung Chan Award Candidate Wavelength Tunable Light Source with multi-modulation frequencies for frequency-domain bio-photonic applications
Yao-Chung Chan;Ming-Mao Lee;Sheng-Hao Tseng;Ming-Che Chan

In this work, we present a novel scheme of a simple, fast (MHz to GHz), intensity-modulated light source of various wavelengths with high modulation depth in the 0.7~1.35 micrometers bio-penetration window. A frequency-domain diffuse optical spectroscopy was utilized as a demonstration example.

Paper No.  2017-THU-P0601-P002
Cheng Chia-Yi Award Candidate Microstructural changes in leaf aging at epidermis layer observed by high resolution Full Field Optical Coherence Microscopy (FF-OCM)
Cheng Chia-Yi;Anna Tulsi;Chakraborty Sandeep;Chiou Arthur;Kuo Wen-Chuan

We report a high resolution FF-OCM with a supercontinuum light source to investigate the microstructural changes in epidermis layer of maple leaves which showed significant deterioration in red leaves (aged) compared to green leaves. Our approach can be useful in developing hand-held FF-OCM system for quality maintenance in agricultural field.

Paper No.  2017-THU-P0601-P003
Ting-Li Lin Award Candidate Sensitivity Enhancement of Functionalized MoS2 Based Plasmonic Biosensors for Detection of Pregnancy Associated Plasma Protein A2 (PAPP-A2)
Ting-Li Lin;Nan-Fu Chiu

The development of carboxyl-functionalized molybdenum disulfide (MoS2-COOH) has led to a new trend in the biosensing field. In summary, the excellent binding affinity, biocompatible and high sensitivity suggest the potential of the clinical application of this MoS2-COOH-based SPR chip detection method for in vitro diagnostic and point-of-care testing devices.

Paper No.  2017-THU-P0601-P004
Chun Ling Yen Award Candidate Label free of hybridized asymmetric metamaterial resonator with high Q factor
Chun Ling Yen

A resonance-based sensing device for biomedical applications which is operation at 30 THz. When the biological cells are attached to the device surface, its resonance frequency will shift, making possible calibration-free, speedy biological cell detection.Focus on the devices as a refractive index detector with high-Q to improve the resolution.

Paper No.  2017-THU-P0601-P005
Chuan-Hsiang Yu Award Candidate Cost-Effective Wireless Multichannel NIRS Embedded System
Chuan-Hsiang Yu;Chia-Wei Sun

Near-infrared spectroscopy (NIRS) is a popular technique for therapeutic applications in recent years. However, most of the commercial NIRS systems are expensive, and it limits the prevalence. We built an inexpensive, wearing-convenient, light in weight, and rechargeable NIRS system. In this presentation we test our system with mental algorithm task.

Paper No.  2017-THU-P0601-P006
Yung-Chun Tsai Award Candidate Sensitivity Enhancement Of Functional Single Layer MOS2 Based Surface Plasmon Resonance Biosensor For Detection Of CA19-9.
Yung-Chun Tsai;Ting-Li Lin;Nan-Fu Chiu

In this experiment, we present a fast and stable process carboxyl modified molybdenum disulfide (MoS2-COOH) as an ultra-sensitive surface plasmon resonance (SPR) sensing layer. The characteristic of high sensitive and biological affinity MoS2-COOH bio-chip is a novel and advantage technique.

Paper No.  2017-THU-P0601-P007
Han Ko Award Candidate Investigating the iron oxide nanoparticles on selective wavelength photothermal therapy for antibacterial activity
Han Ko;Chih-Chia Huang

We demonstrate a high photothermal conversion efficiency iron oxide nanoparticles with extending absorption spectrum from UV to NIR. In environment area, we present the solar driven photothermal antibacterial activity. For therapeutic application, we choose the high tissue transmittance 808nm NIR laser to prove the inhibition of microbial infection.

Paper No.  2017-THU-P0601-P008
Yung-Ching Chang Award Candidate Dual-function Tags For Photothermal Therapy and Raman Imaging of Glioblastoma Cells
Yung-Ching Chang;Li-Ching Huang;Yi-Syuan Wu;Chun-I Sze;Shiuan-Yeh Chen

In this work, dual-function tags were developed to apply on photothermal therapy and Raman imaging of GBM (Glioblastoma Multiforme), a fatal brain tumor. Due to the LSP-enhanced photothermal conversion efficiency and SERS effect of core-satellite gold nanoparticles, the tags have the abilities to kill and specifically image GBM cells.

Paper No.  2017-THU-P0601-P009
Meng-Syuan Jian Award Candidate Dynamic Phase Analysis on Spectral Interferometry-based Surface Plasmon Resonance Biosensing
Meng-Syuan Jian;Meng-Huan Tsai;Chung-Hsuan Chen;Chou-Yun Hsu;Shih-Hsiang Hsu

A spectral interferometry-based surface plasma resonator system demonstrates the Influenza DNA sensitivity as 0.149 μg/mL. Its phase related association and dissociation constants obtained from characterization are 9759.72 (s-1 M-1) and 0.0438 (s-1), respectively. To our knowledge, it is the first time to derive the dynamic phase analysis in telecommunication wavelengths.

Paper No.  2017-THU-P0601-P010
Tien-Yu Hsiao Award Candidate Intraoperative Optical Imaging for Brain Tumor Surgery
Tien-Yu Hsiao;Xin-Rui Liu;Kai-Shih Chiu;Yun-Qian Li;Chun-Jung Huang;Shan-Ji Li;Ching-Po Lin;Chia-Wei Sun

Accurate surgeries hold the key to good prognoses of brain tumors. An intraoperative optical intrinsic signal imaging is employed to distinguish lesions. The result shows vessels in tumor region have poor ability to provide oxygen.

Paper No.  2017-THU-P0601-P011
pan yi Award Candidate Implementation of a three-dimensional tracking system with harmonic generation microscopy diagnosis for multiple facial actinic keratoses
pan yi

We establish a high definition face tracking system with three-dimensional coordinate mapping and apply this 3D face tracking system to determine the location and treatment efficacy of multiple facial AKs in clinical follow-ups. Finally, we investigate the clinical applicability of HGM imaging for diagnosis of AK in vivo.

Paper No.  2017-THU-P0601-P012
Mei Ru Chen Award Candidate Differentiation of glioma and white matter using polarization-sensitive optical coherence tomography
Mei Ru Chen

In this study, we classified birefringent and non-birefringent tissues by statistical methods. Since tumor is birefringent tissue and white matter is not, we successfully drew the boundary between tumor and white matter using PS-OCT. Our goal is to provide precisely maximal resection for operators.

Paper No.  2017-THU-P0601-P013
Pei Yu Lai Award Candidate Angiography and Lymphangiography for Study of Skin Melanoma Mice Using Optical Coherence Tomography
Pei Yu Lai;Tim-Han Lin;Ya-Shuan Chou;Chung-Hsing Chang;Wen-Chuan Kuo

We have developed a multi-contrast, label free optical coherence tomography (OCT) imaging system, which can provide the information of microstructure and microcirculatory system simultaneously. Using this technique, we observed angiogenesis, lymphangiogenesis and structural information in the ear of the skin melanoma mice in vivo.